Аннотация:
Free radical homeostasis state at patients with chronic alcoholic hepatitis being on standard treatment and combined therapy with melaxen or epifamin has been investigated. Biochemiluminescence parameters in blood serum point out to intensification of free radical processes and inhibition of antioxidant defense of organism of patients with liver alcohol lesion. At the same time superoxide dismutase activity in blood serum increased, that, evidently, had compensatory significance. After leading of standard therapy a decline of oxidative stress expression was observed. Incorporation to basic treatment of melaxen or epifamin provided more expressed antioxidant effect and accompanied by more sufficient correction of antioxidant status of organism, that confirmed by changing of biochemiluminescence parameters and superoxide dismutase activity. Obviously, it is related to antiradical properties of melatonin, the level of which can increase under action of these preparations.
Ключевые слова:
chronic alcoholic hepatitis, free-radical processes, antioxidant system, superoxide dismutase, epifamin, melaxen