Аннотация:
Allosteric modulators of CB1 receptors that modify orthosteric ligands binding properties and change endocannabinoid neurotransmission efficacy are discussed. Org 27569, Org27759, Org29647 and their derivatives, phenylure a derivate PSNCBAM-1 and "Pepcans" polypeptides are negative allosteric modulators and inhibit endocannabinoid transmission. Positive allosteric modulators include eicosanoidlipoxin A4 and dopamine reuptake inhibitors RTI-370, RTI-371 and JHW-007. It is supposed that agents Org 27569, Org27759 and Org 29647, included in the resolution of the Russian Federation Government №681 from 30.06.1998, have neither addictive potential nor potentiate addictive properties of the CB1 receptors agonists.
Ключевые слова:
allosteric modulators, cannabinoid receptors, restriction turnover