Аннотация:
To compare the effects of three cortexolone (substance S) derivatives we used an animal model of alcoholism – long-term alcohol consumption followed by deprivation phase in rats. We found that repeated treatment with S5 (cortexolone-acetate-pivaloat) significantly suppressed relapse-like alcohol drinking determined in a "free-choice" paradigm after extended period of abstinence. Furthermore S5 decreased morphine – and cocaine-craving and prevented relapse after long-term period of withdrawal in the "place-preference" model of drug abuse in rats. Possible mechanisms that underlie cortexolone derivatives effects and potential perspectives for S5 to be used in the post-abstinent period as a novel therapeutic intervention for treatment and prophylaxis of the relapse in alcohol and drug-addicts are discussed.
Ключевые слова:
glucocorticoid receptors, cortexolone derivatives, alcohol consumption, morphine, cocaine, conditioned place-preference