Аннотация:
In this article authors present theoretical material regarding the role of endogenous melatonin in pathophysiology of alcohol withdrawal syndrome (especially alcohol insomnia) and current clinical data regarding the efficacy and safety of exogenous melatonin (Melaxen) administration in alcohol withdrawal syndrome and alcohol-related insomnia. The advantages of Melaxen over benzodiazepines in terms of more benign side effect profile, better tolerability, zero cross-tolerance with alcohol, positive modulation of hepatic function, zero risk of dependence and zero risk of secondary withdrawal syndrome are also marked and stressed. Scientifically based algorithm of clinical use for Melaxen in alcohol withdrawal syndrome and alcohol insomnia is proposed. Indications for Melaxen use in these situations are described.
Ключевые слова:
melatonin, Melaxen, circadian rhythms, desynchronosis, alcohol dependence, alcohol withdrawal syndrome, alcohol insomnia, postalcohol depression, alcoholic hepatitis, hepatoprotectors, antioxidants.