Аннотация:
The term "energy drinks" refers to beverages that contain caffeine in combination with other ingredients: vitamins B, taurine, sugar derivatives (glucuronalactone, ribose) and others. Although energy drinks are popular among young consumers, there has been little research regarding delayed effects of energy drink consumption during adolescence on the behavior as well as alcohol preference as adults. Therefore, current investigation was aimed to evaluate the effects of energy drink consumption during adolescence in Wistar male rats. This study was carried out using a total number of 60 male Wister rats aged 30 days at the start of the experiment. Rats were randomly divided into two groups, housed individually with free choice entrance to the drink or water in "two-bottle" model (n = 40) or water as control (n = 20). Spontaneous locomotor activity was continuously monitored over the whole period of the experiment. Exposure to the drink (30 – 60 g/rat/day) for 30 consecutive days didn’t cause any changes in the body weight compare to control rats. Spontaneous locomotor activity was significantly increased during the night (the rat active phase) without changes in circadian locomotor activity rhythm. The light/dark test, commonly used in rodent to investigate unconditioned anxiety-like behavior, showed that time in the light compartment and percent distance in the light were higher in the experimental group compare to control rats suggesting the anxiolytic efficacy of the drink. Finally alcohol intake, evaluated in "two-bottle free choice" paradigm (10% ethanol/water) was not changed significantly in the adult rats, consumed a drink during adolescence. These data are discussed with reference to the potential combined caffeine-taurine effects to reduce possible negative consequences of caffeine use. However these interactions remain to be further examined in humans and experimental models.
Ключевые слова:
alcohol-free energy drink, caffeine, taurine, adolescence, behavior, circadian rhymes, anxiety, alcohol