Аннотация:
The molecular genetics represents important branch of biomedical researches as many processes in organism are determined genetically. It is necessary to consider a role of a molecular and genetic factor for successful symptomatic treatment of drug-addicted patients. It is connected with that fact that biochemical indicators can reflect the metabolic processes proceeding in an organism of people with drug addiction, and determined by a genetic factor. It is possible to carry detoxication of narcotics, their penetration into tissues of a brain and processes of drugs removal from an organism to such processes. At drug-addicted subjects there is an interaction between a hepatic and kidney parenchyma during the utilization of narcotics in liver with the subsequent their removal through kidneys. That’s why the condition of detoxication genes in hepatocytes is one of the indicators in processes of an inactivation of narcotic preparations and their efficiency. The carriage of two polymorphic variants CC on genes of UGT2B7 and UGT1A1 can be considered as adverse sign of genetic polymorphism at the drug-addicted people which, on the one hand, will lead to accumulation of indirect bilirubin in blood, and, on the other hand, will induce to increase a drug dose for achievement of narcotic effect.
Ключевые слова:
drug addiction, detoxication, genetic polymorphism