Аннотация:
The high risk of addiction disease, as well as neurotoxic potential of amphetamines, makes the study of the detailed mechanisms of interaction of psychostimulants with brain neurotransmitter systems one of the actual problems in modern addiction medicine. The aim of the work was to study the influence of antagonist of metabotropic glutamate (mGlu) receptors of the 5th subtype 6-methyl-2 – (phenylethyl) pyridine hydrochloride (MPEP) on development of stereotypical behavior of rats, as well as on intensity of lipid peroxidation (POL) processes in brain structures of animals treated with amphetamine subchronically. The experiments were performed on male Sprague–Dawley rats. It was found that administration of amphetamine was accompanied by development of stereotypies along with marked increase in intensity of LPO processes in brain structures of rats. The mGlu receptor antagonist MPEP reduced severity of stereotypy behavior. It also partially prevented increase in level of LPO products in brain structures of rats induced by amphetamine. Results of our study indicate significant involvement of mGlu receptors of 5th subtype in mechanisms of neurotoxic effects of amphetamine.
Ключевые слова:
amphetamine, metabotropic glutamate receptors, stereotyped behavior, lipid peroxidation, striatum.