Аннотация:
Recent decades, it has been found that intake of psychostimulant drugs during pregnancy can lead to developmental delays and behavioral disorders in their offspring. However, the question is about influence of sex on behavior of rat offspring, subjected to prenatal administration of caffeine, remains poorly understood. The aim of this work was to elucidate role of the sex factor on indicators of anxiety and locomotor activity in male and female rats subjected to prenatal exposure to caffeine. Experiments were performed on males and females of Wistar rats, whose mothers received a solution of caffeine (1 g/l of standard bottled drinking water) throughout their gestation as the only source of fluid. A more pronounced increase in level of anxiety and decrease in motor activity in males was established compared with female rats subjected to caffeine exposure in utero. The results of our study confirm the need for behavioral studies in animals of both sexes when studying the prenatal effects of caffeine.
Ключевые слова:
female and male rats, caffeine, anxiety, motor activity.