Аннотация:
Background. Currently, it is important to study the neurocognitive features of the pathogenesis of alcohol dependence, as this will clarify the brain mechanisms of cognitive activity in alcoholism and link these data with the effectiveness of rehabilitation of patients. The "Go / No-go" test is one of the most common tasks used to determine the main deterrent control that involves decision-making processes. The use of EEG will allow to objectively assess the nature of changes in cognitive functioning in alcohol dependence.
Aim: to study the features of cognitive functioning and parameters of EEG coherence in persons with alcohol dependence in response to the Go/No-go problem.
Methods. 53 patients (37 men, 16 women) with a diagnosis of mental illness and behavioral disorders related to psychoactive substance use, the alcohol dependence syndrome (F10.2 according to ICD-10), after the removal of intoxication were examined. 20 mentally and somatically healthy persons of comparable sex and age were examined as a control group. Cognitive functioning was assessed using the Go/No-go computer test. 16-channel EEG was recorded, the coherence values of alpha, beta and theta rhythms at rest with eyes open and during the cognitive test were analyzed.
Results. In the group of patients with alcohol dependence syndrome, a statistically significant increase in the number of errors on the Go signal compared to the healthy control group was found, no statistically significant differences were found on the No-go signal. When performing the Go/No-go task in the group of patients with alcohol dependence, there are more extensive changes in the integration of the cerebral cortex, which are to reduce the consistency of bioelectric brain activity in a wide frequency and regional range
Ключевые слова:
alcohol dependence, cognitive control, Go/No-go, electroencephalography, coherence.