Аннотация:
Aim: to create a new personalized approach to assessing the rehabilitation potential of patients with alcohol dependence based on the diagnosis of cognitive deficit and its neurophysiological markers.
Methods. 81 patients aged from 29 to 55 years were examined with a diagnosis of: mental disorders and behavioral disorders associated with the use of psychoactive substances, alcohol dependence syndrome. All patients received standard treatment for alcohol withdrawal syndrome (AAS) and post-withdrawal disorders. Quantitative clinical, cognitive, and neurophysiological examinations of patients with alcohol dependence were performed twice: after detoxification (1 point) and at the end of the course of therapy (2 point). The duration of the main course of therapy is 14 days. The clinical condition of patients with alcoholism was assessed on the Hamilton anxiety scale (HARS), the General clinical impression scale (CGI-s), the Yale–Brown scale, and the social adaptation self-assessment scale (SASS). The level of cognitive deficits was assessed using computerized tests: Go/Nogo, Corsi, and Stroop. The EEG was recorded at rest for 2 minutes.
Results. Based on the data obtained, regression models of rehabilitation potential were constructed that describe up to 78% of the variance in the values of clinical assessments after the course of therapy.
Conclusion. the mathematical approaches used in this work, as well as The results obtained, allow us to clarify the role of cognitive and neurophysiological mechanisms of alcohol dependence in relation to the effectiveness of therapy.
Ключевые слова:
аlcohol dependence, prognosis, mathematical models, rehabilitation, electroencephalography, cognitive functions.