Аннотация:
Introduction. The study of the oxidative stress features in various pathologies and the search of compounds that are promising for creating new effective domestic pharmaceutical products are important scientific problems.
Aim: to study the products of oxidative damage of biomacromolecules – lipids (TBA-reactive products, TBA-RP), proteins (carbonylated proteins, CP) and DNA (8-hydroxy-2’-deoxyguanosine, 8-OH-2’dG) – in the blood plasma of healthy individuals, patients with depressive disorder and patients with alcoholism after incubation of their blood with the known antioxidant and neuroprotector carnosine (β-alanyl-L-histidine) or the normotimic and potential antioxidant lithium pyruvate.
Methods. We used the blood of 28 practically healthy people, 50 patients with depressive disorder (F32 or F33) and 36 patients with alcohol dependence (F10.21 or F10.30). Appropriate commercial kits were used to determine oxidized biomacromolecules in blood plasma.
Results. Differences were found both in the initial level of peripheral markers of oxidative stress in patients with different pathologies, and differences in the effects of carnosine and lithium pyruvate on the products of oxidative modification of plasma proteins, lipids, and DNA in patients with depressive disorder and alcoholism.
Conclusion. It is concluded that the levels of peripheral markers of oxidative stress are highly variable in different pathologies and that more extensive research is needed to increase the actual data on oxidative stress and the effects of compounds with antioxidant properties.
Ключевые слова:
carbonylated proteins, TBK-reactive products, 8-hydroxy-2’ – deoxyguanosine, depressive disorders, alcoholism, carnosine, lithium pyruvate.