Аннотация:
Aim: to identify the features of inhibitory (restraint) control in patients with alcohol dependence, as well as to establish significant relationships with the main clinical and dynamic indicators.
Methods. We examined 71 patients with alcohol dependence (53 men and 18 women) aged 18 to 60 years (the average age of patients at the time of the study was 45.21 ± 10.1 years). Assessment of cognitive functions (inhibitory control) was carried out using computerized Go/No–go tests and a modified Stroop test. Data from psychometric scales: HARS, SHAPS, OKS, ASI and PACS, as well as drug history data from patients’ medical records were used as clinical and dynamic variables.
Results. It was found that 42.3% of patients had a deficit of behavioral inhibition in the Go/No–go test, in which an earlier start of the first alcohol test was found compared to the group of patients without impaired behavioral inhibition (p = 0.008). Also, data analysis revealed statistically significant inverse (negative) correlations between the duration of the last remission and Stroop test scores (rs = –0.357; p=0.014).
Conclusion. Alcohol dependence is characterized by a violation (deficiency) of inhibitory control in the form of a violation of behavioral inhibition, as well as a decrease in interference control, which are accompanied by an earlier age at the first alcohol test and a shorter duration of alcohol remission.
Ключевые слова:
alcohol dependence, inhibitory control, behavioral inhibition, interference control, Go/No–go, Stroop test, clinic, remission.