Аннотация:
Background. Mental and behavioral disorders, characterized by a dominant addiction of non-chemical genesis, constitute the least theoretically developed group that is resistant to therapy. The phenomenon of codependency is currently considered as a post-traumatic stress disorder and does not have a single and precise definition; the genetic component of this conduct disorder is not well understood.
Aim: to study the genetic component of addictive disorder of non-chemical origin in the form of codependency phenomenon.
Methods. The study included 240 probands from two comparison groups: women with the phenomenon of codependency who do not abuse alcohol (F60.7; n=120) and men with alcoholism (F10.212; F10.222; n=120). The clinical and genealogical characteristics of women with codependent behavior disorder and men dependent on alcohol were studied; A comparative analysis of pedigrees was carried out, taking into account relatives of the 1st and 2nd degrees of kinship (n=6735).
Results. An analysis of the frequencies of alcohol dependence among relatives of I, II and both degrees of relationship of women with codependent conduct disorder and women of the control group revealed statistically significant differences among relatives of all degrees of relationship with a predominance of secondary alcoholism in the pedigrees of women with the presence of the phenomenon of codependency (p<0.001). The frequency of alcoholism among fathers and brothers of co-dependent women is 66.7% and 60.5%, respectively. Comparison of the frequencies of alcoholism among relatives of I, II and both degrees of kinship of co-dependent women and alcohol-dependent men established the absence of statistically significant differences and a high level of similarity in the distribution of secondary alcoholism in the pedigrees of women with the presence of the phenomenon of codependency and alcoholic men (p = 0.411÷0.640).
Conclusions. The hereditary burden of alcoholism in the pedigrees of women with a disorder of the type of dependent personality in the form of the phenomenon of codependence indicates the presence of a genetic factor in the pathogenesis of the analyzed non-chemical form of dependent behavior. The presence of a common genetic component in the development of alcohol dependence and the phenomenon of codependence can be considered as evidence of the commonality of the genetic basis of alcoholism and the phenomenon of codependence and allow us to interpret the phenomenon of codependence as a variant of the phenotypic dispersion of hereditary burden of alcoholism.
Ключевые слова:
addiction; co-dependency; alcoholism; pedigree; hereditary burden; psychogenetics; genetic determinism; behavioral genetics.