Аннотация:
Polymorphic loci of the dopamine receptor gene DRD4 (VNTR) and the dopamine transporter gene SLC6A3, as well as their stable combinations (pseudo-haplotypes), were studied in 169 patients with addiction to synthetic drugs. The control group consisted of 183 healthy individuals. All subjects were male and Caucasian. It was found that in both samples the allele of the DRD4 gene (VNTR) with 4 repeats and the genotype represented by 4 tandem repeats were more common. Significant differences in the frequency of occurrence of polymorphic variants of the dopamine receptor gene DRD4 (VNTR) were identified between the group of patients using synthetic cathinones and cannabinoids and healthy people. Thus, in patients with polysubstance dependence compared to healthy people, the allele with 3 repeats is less common (p <0.02), the allele with 6 repeats is more common (p <0.03) and the genotype 4/6 is more common (p <0.01) dopamine receptor gene DRD4 (VNTR). No differences in the frequency of occurrence of polymorphic variants of the dopamine transporter gene SLC6A3 were found. Based on the two studied polymorphic loci, 15 pseudo-haplotypes were identified in individuals dependent on synthetic drugs, and 13 in healthy men. Pairwise linkage disequilibrium was detected for the polymorphic loci of the SLC6A3 VNTR and DRD4 gene, located in cis, with a probability of P <10-5 , only in healthy people, in dependent patients no linkage is observed.
Ключевые слова:
synthetic cannabinoids, synthetic cathinones, dopamine transporter, dopamine receptor, gene polymorphism, pseudo-haplotypes.