Аннотация:
The aim of this study was to investigate the role of gastric receptors in the mechanisms of development of tolerance to ethanol. To reach this purpose we used repeated administrations of the ethanol in the same dose, but in different volumes and different concentrations. It was established that the administration of ethanol at a dose of 2 mg/kg in all used concentrations and volumes had no significant effect on anxiety level of rats. It was found that treatment with ethanol in the volumes of 15.5 ml/kg and 40 ml/kg produced a significant increase in a locomotor activity of rats on the first day of the experiment. The psychostimulant effect of ethanol in the average volume (15.5 ml/kg) was unstable, while the administration of its maximum volume (15.5 ml/kg) increased locomotion of rats during all 7 days of observation. It was shown that on the first day of the experiment, the treatment with ethanol at a dose of 2 mg/kg caused an analgesic effect only when the average volume of a solution of ethanol was admitted. On the next day of the experiment ethanol produced the analgesic effect in all the concentrations and volumes Subsequent administration of ethanol led to the development of tolerance to this effect. Thus, our results confirmed our hypothesis that tolerance to the effects of ethanol initially may be due to its effect on the activity of opioid receptors in the stomach. It indirectly might to leads to alteration in the activity of the central component of the endogenous opioid system.
Ключевые слова:
ethanol, tolerance, blood-brain barrier, opioid receptors, painful sensitivity, anxiety, locomotion, rats